![]() These chromosomal events are generally conserved across eukaryotes and have been extensively studied ( Handel and Schimenti, 2010).ĭespite being a critical pivot point in the life cycle, meiotic initiation - the decision to embark on the one and only one meiotic program per generation - has been less studied, perhaps because the regulation of meiotic initiation is less conserved ( Kimble, 2011). In most organisms, meiotic chromosome segregation depends on the pairing, synapsis, and crossing over of homologous chromosomes during prophase of meiosis I. We conclude that, in mice, the robust amplification of this extraordinarily broad transcription program by a common factor triggers initiation of meiosis.Ī key feature of sexual reproduction is meiosis, a specialized cell cycle in which one round of DNA replication precedes two rounds of chromosome segregation to produce haploid gametes. STRA8 binds its own promoter and those of thousands of other genes, including meiotic prophase genes, factors mediating DNA replication and the G1-S cell-cycle transition, and genes that promote the lengthy prophase unique to meiosis I. This broad gene expression program is directly upregulated by STRA8, encoded by a germ cell-specific gene required for meiotic initiation. ![]() Here, we examined cells undergoing meiotic initiation in mice, and we found that initiation involves the dramatic upregulation of a transcriptional network of thousands of genes whose expression is not limited to meiosis. However, the mechanisms governing this initiation of meiosis remain poorly understood. ![]() The germ line provides the cellular link between generations of multicellular organisms, its cells entering the meiotic cell cycle only once each generation.
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